Sunday, 15 December 2024

Hip Replacement Surgery Cost in India

 Hip Replacement Surgery Cost in India

  • Single Hip Replacement Surgery Cost in India start from INR 252,000 (USD 3000).
  • Bilateral Hip Replacement Surgery Cost in India start from INR 588,000 (USD 7000).
  • Total Hip Replacement Surgery Cost in India start from INR 462,000 (USD 5500).
  • This cost can be less or more depending upon the hospital, experience of doctors, quality and type of implant used and many more parameters.







Hip replacement cost is one of the biggest factors behind the visit of thousands of patients to India. It is a costly procedure, especially in Western countries. Since it is a complex surgery, it must only be performed by a highly experienced and trained orthopedic doctor.
The cost of hip replacement surgery is bound to be high in many countries. This is the case with a majority of Western countries, including the US.

But, the huge cost in the western countries restricts patients from undergoing the treatment which encourages them to look for cost-effective options and alternatives. This is the reason why hip replacement surgery in India is so popular. The country is known for offering quality medical treatment at an affordable price.

Factors Affecting the Hip Replacement Surgery Cost in India

  • Type and quality of implant used
  • The type of hospital room preferred
  • Experience of the surgeon
  • Cost of medicines and other consumables
  • Management of post-surgery complications
  • The total duration of hospital stay
  • Rehabilitation and physical therapy costs
Type of Hip Replacement SurgeryPrice in (₹)Price in ($)
Single hip replacement surgeryINR 252,000USD 3,000
Bilateral hip replacement surgeryINR 588,000USD 7,000
Total hip replacement surgeryINR 462,000USD 5,500

What are the different types of Hip Joint Replacement performed by Indian Hospitals?

There are different types of hip replacement surgery. It depends on the level of intervention needed during the surgery and the extent of damage that needs to be repaired.

The orthopedic surgeon assesses the condition of the patient. Then they advise which type of hip replacement the patient should undergo. The common types of hip replacement surgeries include the following:

Total hip replacement surgery

  • The natural and damaged hip joint is completely removed in this procedure. It is replaced with a prosthetic joint.
  • This surgery helps reduce hip pain completely and also improves the quality of life.
  • Recovery after total hip replacement, yet, takes a long time.

Partial hip replacement surgery

  • The damaged hip joint is partially removed and replaced with the prosthetic joint.
  • Recovery after partial hip replacement takes less time as compared to total hip replacement.

Hip resurfacing surgery

  • It is an alternative to total hip replacement.
  • It helps reline the damaged hip joint rather than replace it altogether.
  • It is done by creating a larger hip ball than usual, which helps prevent dislocation of the hip joint.

Double hip replacement surgery

  • Also known as Bilateral Total Hip Replacement, is carried out on both hips.

Hip replacement revision

  • Occasionally, the initial hip replacement operation is unsuccessful, or the prosthetic that was attached to replace the original joint is ineffective.
  • It might become displaced or infected.
  • The surgeon might then do another procedure. This is referred to as revision hip replacement surgery. It aims to fix the issue during the initial operation.

Minimally invasive hip replacement

  • It aims at delivering the same benefits of total or partial hip replacement.
  • The surgery makes sure that the patient is able to recover as quickly as possible and return to the daily chores of life.
  • This surgery is conducted with the help of smaller tools and instruments. These are inserted through several small incisions made around the hip area, instead of a single, large incision.

Robotic hip replacement surgery

  • There are three different types of robotic systems, depending on how much control the user has over the robot: passive, semi-active, and autonomous.
  • The passive systems don’t function on their own.
  • Depending on the patient- and instrument-centred reference points, they are known as computer assisted or navigation systems. They give the surgeon procedural advice and direct the placement of the surgical tool.
  • Robotic surgery can help surgeons by providing advanced targeting, visualizing, and task execution with precision that goes beyond human abilities.
  • With results that can be replicated, it offers a high level of repetition and eliminates variation in surgical outcomes.
  • It aids in cutting bone, placing implants, and directing surgeons in more precise instrument positioning.
  • Due to the ability to treat the bone as a fixed object, it is perfect for total joint replacements like hip joints.

Types of Implants for hip replacement

  • The prosthetic implant is generally made of cobalt chrome or titanium-aluminum alloy. These alloys are really hard, durable, and high strength. These are able to work well even when the object moves against another object (as in the case of a joint).
  • Another material sometimes used for the creation of prosthetics is polyethylene plastic. This material has a high life and is extremely lightweight as compared to other materials. Depending on the type of material used, the life of a prosthetic placed during hip replacement may range from 10 to 25 years.

Know more about the different materials used in hip replacement implants.

Common causes of Hip disorders

  • Osteoarthritis: Osteoarthritis of the hip is caused when the joint cartilage and the bones underneath the joint starts to degenerate
  • Femoral head Fracture: Femoral head Fractures are the rare injury that is associated with posterior or anterior hip dislocations mostly caused due to high energy trauma (such as automobile collision).
  • Avascular Necrosis: Also known as Osteonecrosis, is caused when the bones start to have a loss of blood.

What are the signs that you may need a hip replacement?

Following are the symptoms indicating the need for the Hip Replacement

  • Tried all non-operative treatment modalities for pain relief.
  • Constant and continual pain in the hip, knee, or groin.
  • Difficulty completing daily tasks such as walking, bending, etc.
  • Cartilage thinning and grinding bones.
  • Instability of the hip joint resulting in disbalance.
  • Difficulty sleeping at night due to pain.

What are the diagnostic tests for hip replacement in India?

The Orthopaedic Evaluation

Indian Orthopedic surgeon conducts thorough diagnostic and specialized tests. The orthopedic evaluation will typically include:
  • Aspiration – The doctor may aspire some amount of liquid from the hip joint and examine out to see if the pain is not a result of rheumatoid arthritis. The degeneration of the hip could also be a result of an infection in the joint, which can be figured out through aspiration.
  • Bone densitometry test – This test is used to measure the density of the bones. It is a non-invasive test that can confirm whether the patient is in immediate need of hip replacement.
  • CT and MRI Scans – These scans are used to see three-dimensional pictures of the hip joint. It helps to identify the actual amount of destruction affecting the hip joint.
  • Arthrogram – In this test, a dye is injected into the hip joint to see the surrounding cavity and the amount of degeneration of the bones.

Preparation before hip replacement surgery in India

We are listing some of the to-do items before the surgery below:

  • Learn everything about the hip replacement procedure and the associated risks and complications.
  • Clear your queries from the surgeon.
  • Consider how the surgery will impact your work and daily schedule.
  • Meet a physical therapist in advance and decide about your rehabilitation and recovery plan.
  • Make sure to test drive your walker or crutches before the hip surgery.
  • Ask your close friends or family members to be there for you at home during the recovery period.

    Tuesday, 7 June 2016

    Bone marrow (stem cell) transplant




    "A bone marrow transplant is a medical procedure performed to replace bone marrow that has been damaged or destroyed by disease, infection, or chemotherapy. This procedure involves transplanting blood stem cells, which travel to the bone marrow where they produce new blood cells and promote growth of new marrow. "

    Bone marrow is the spongy, fatty tissue inside your bones. It creates the following parts of the blood:

    • red blood cells, which carry oxygen and nutrients throughout the body
    • white blood cells, which fight infection
    • platelets, which are responsible for the formation of clots

    Bone marrow also contains immature blood-forming stem cells known as hematopoietic stem cells, or HSCs. Most cells are already differentiated and can only make copies of themselves. However, these stem cells are unspecialized, meaning they have the potential to multiply through cell division and either remain stem cells or differentiate and mature into many different kinds of blood cells. The HSC found in the bone marrow will make new blood cells throughout your lifespan.

    A bone marrow transplant replaces your damaged stem cells with healthy cells. This helps your body make enough white blood cells, platelets, or red blood cells to avoid infections, bleeding disorders, or anemia.


    Healthy stem cells can come from a donor, or they can come from your own body. In such cases, stem cells can be harvested, or grown, before you start chemotherapy or radiation treatment. Those healthy cells are then stored and used in transplantation.

    When are bone marrow transplants used?

    If you have a bone marrow transplant, your unhealthy bone marrow will be replaced with healthy stem cells. You may need a bone marrow transplant because you have a condition that affects your bone marrow or your red blood cells. These include the following.

    • Cancers that affect your bone marrow, such as leukaemia, lymphoma and myeloma.
    • Conditions affecting your blood cells, such as sickle cell anaemia and thalassaemia.
    • Conditions that affect your immune system.

    The stem cells can come from another person (a donor) – this is called an allogeneic transplant. For example, you may have a related donor such as a brother or sister, or a matched unrelated donor. If the stem cells come from your identical twin, this is called a syngeneic transplant. The cells can also come from your own bone marrow, which is called an autologous transplant. But this can only happen if your stem cells are removed when they are healthy.

    Having a stem cell transplant means you may be able to have higher doses of chemotherapy treatment. Treating cancer with high-dose chemotherapy and a bone marrow transplant may cure your cancer, keep it under control or stop it coming back. Examples of conditions treated by an autologous stem cell transplant include myeloma and lymphoma.

    Types of Bone Marrow Transplant

    There are two major types of bone marrow transplants. The type used will depend on the reason you need a transplant. 

    Autologous Transplants

    Autologous transplants involve the use of a person’s own stem cells. They typically involve harvesting your cells before beginning a damaging therapy to cells like chemotherapy or radiation. After the treatment is done, your own cells are returned to your body.

    This type of transplant isn’t always available. It can only be used if you have a healthy bone marrow. However, it reduces the risk of some serious complications, including GVHD.


    Allogeneic Transplants

    Allogeneic transplants involve the use of cells from a donor. The donor must be a close genetic match. Often, a compatible relative is the best choice, but genetic matches can also be found from a donor registry.

    Allogeneic transplants are necessary if you have a condition that has damaged your bone marrow cells. However, they have a higher risk of certain complications, such as GVHD. You’ll also probably need to be put on medications to suppress your immune system so that your body doesn’t attack the new cells. This can leave you susceptible to illness.

    The success of an allogeneic transplant depends on how closely the donor cells match your own.

    Preparing for a bone marrow transplant

    Once you’ve decided to have a bone marrow transplant, your doctor or nurse will explain how to prepare for it. They will start looking for a suitable stem cell donor if your stem cells are coming from another person. Your donor will ideally be a close relative (usually a brother or sister). This is because their blood cells are likely to be similar to yours. If your doctor can’t find a relative who is a close match, they will look for someone who isn’t related to you.

    You and any possible donors will need to have some blood tests. Your doctor will compare your blood cells with those of the donor to see whether the donor is a good match for you. Your doctor will ask the donors about their medical and family history too.

    If your own stem cells are being used, you may need to have a general anaesthetic beforehand. This means you’ll be asleep during the procedure. You’ll also be asked to follow fasting instructions. This means not eating or drinking anything, usually for about six hours, before your surgery. It’s important to follow your anaesthetist’s advice. This method of collecting stem cells is now used less commonly. Instead, stem cells are more commonly collected from the blood stream.

    After you have a bone marrow transplant, you’ll need to stay in a hospital room on your own for a while. This could be for about four weeks. It will reduce your chances of catching an infection while your immune system recovers. When you’re packing your hospital bag, take some personal things with you, such as photographs, books and magazines, to make your room more homely. Taking a mobile phone, electronic tablet or laptop might help you to pass the time and keep in touch with relatives and friends.

    Your nurse or doctor will discuss with you what will happen before, during and after your procedure, including any pain you might have. If you’re unsure about anything, don’t be afraid to ask. No question is too small. It’s important that you feel fully informed so you feel happy to give your consent for the procedure to go ahead. You’ll be asked to do this by signing a consent form.

    Alternatives to a bone marrow transplant

    Doctors are now using bone marrow transplants to treat a wide range of conditions. But these transplants aren’t suitable for everyone. Your doctor will take your age and general health into account when they decide whether the procedure is right for you. For example, if you’re having a stem cell transplant from a donor, you generally need to be under 70 years old. Your doctor will need to find a compatible stem cell donor if your own cells aren’t suitable.

    Stem cells can also come from blood found in babies’ umbilical cords. Previously, this treatment was only considered suitable for children and small adults. This is because umbilical cord blood contains only small amounts of stem cells. But new research is exploring whether cord blood can be used in all adults.

    What happens during a bone marrow transplant?

    There are usually three steps involved in having a bone marrow transplant:

    • collecting the stem cells from you or a donor
    • having high-dose chemotherapy and/or radiotherapy
    • transplanting the new stem cells

    Collecting the stem cells

    The first step is to collect, or ‘harvest’, the stem cells from you or your donor. There are two main ways to do this. The first way is to collect the stem cells from you or your donor’s blood. This is called a peripheral blood stem cell harvest (PBSCH). The other way is to collect the stem cells directly from you or your donor’s bone marrow.

    If you have a PBSCH, you’ll first be given injections of a growth factor. Most of your body’s stem cells are found in your bone marrow. The growth factor triggers your stem cells to mature more quickly so that they leave your bone marrow and move into your bloodstream. Then your nurse will put two drips into your arms and use a machine to collect these cells from your blood.

    If your stem cells are collected from your bone marrow, you’ll usually have a general anaesthetic, which means you’ll be asleep during the procedure. Alternatively, you may be able to have an epidural. This completely blocks pain from your lower body, but you’ll stay awake during the procedure. Your doctor will then insert a needle into your pelvic bone, or sometimes breast bone, to take stem calls out of your bone marrow.

    The collected stem cells will be given back to you through a drip in your arm. You may need to have other treatments first, such as high-dose chemotherapy.

    High-dose chemotherapy



    Next, you’ll be treated with high-dose chemotherapy, sometimes with high-dose radiotherapy (called total body irradiation) as well. This completely destroys your own bone marrow, creating room for the new bone marrow cells. If you’re being treated for cancer, this step may also aim to destroy any remaining cancer cells in your body. This treatment usually takes about four to seven days. It can make you feel sick or vomit and feel generally unwell. Your doctor or nurse will give you medicines to help relieve this.










    The transplant

    After you’ve finished chemotherapy, the new stem cells will be fed through a drip into your bloodstream. During this simple procedure, you usually lie in bed for a few hours with the drip in your arm. The stem cells will find their way to your bone marrow where they will begin to make new cells. It will take between two and four weeks before there are enough new stem cells in your bone marrow to start making new blood cells.






    What to expect afterwards?

    After a bone marrow transplant, you’re likely to have low levels of blood cells in your body. You may need to have a blood and platelet transfusion to correct this. You’ll also need to take antibiotics to protect you from infections. Your immune system won’t be working properly because your body will contain only low levels of white blood cells. You may need to stay in a room on your own in hospital until your blood cells have gone back up to a safe level.

    A transplant using your own stem cells usually causes fewer side-effects than a transplant using stem cells from a donor. This is because your body is less likely to reject stem cells that have come from its own bone marrow or blood.

    Immediately after a bone marrow transplant, your mouth may feel sore and you may find it difficult to swallow. Your doctor may suggest that you’re fed through a tube placed in one of your veins or directly into your stomach until your mouth recovers.

    The overall success of a bone marrow transplant depends on many factors. These include what condition you have, how far it’s progressed, your age, and how good a match your donors are. If you’d like more information, speak to your nurse or doctor. Donor stem cell transplants are physically and emotionally demanding so it’s important that you prepare yourself and have the support of friends and family. If you’re worried about any aspect of your transplant, speak to your doctor or nurse.

    Recovering from a bone marrow transplant

    How long it takes to recover fully from your bone marrow transplant will depend on whether or not your stem cells were from a donor. This can vary from person to person, so it’s important to follow your doctor’s advice. It can take months or sometimes even years to recover properly as your body gets used to the newly transplanted cells.

    Once the number of blood cells in your body has returned to a safe level, you’ll be able to leave the hospital. You may be advised to avoid eating certain foods, which could be contaminated with bacteria or fungi. These foods include raw or lightly cooked shellfish, blue cheese and raw or undercooked eggs. You’ll also need to be very careful with food hygiene, for example when you prepare, cook, eat out or store food. You should continue to follow this food safety advice for at least six months after being discharged from hospital.

    After a bone marrow transplant, you lose your immunity to common childhood infections. You’ll need to be vaccinated again to protect you against conditions such as tetanus and diphtheria. You’ll usually have these vaccinations about 12 months after your transplant. Your doctor will suggest that you are re-immunised against the flu as well.

    Complications Associated with a Bone Marrow Transplant

    A bone marrow transplant is considered a major medical procedure and increases your risk of experiencing:

    • a drop in blood pressure
    • a headache
    • nausea
    • pain
    • shortness of breath
    • chills
    • a fever

    The above symptoms are typically short-lived, but a bone marrow transplant can cause complications. Your chances of developing these complications depend on several factors, including:

    • your age
    • your overall health
    • the disease you’re being treated for
    • the type of transplant you’ve received

    Complications can be mild or very serious, and they can include:

    • graft-versus-host disease (GVHD), which is a condition in which donor cells attack your body
    • graft failure, which occurs when transplanted cells don’t begin producing new cells as planned
    • bleeding in the lungs, brain, and other parts of the body
    • cataracts, which is characterized by clouding in the lens of the eye
    • damage to vital organs
    • early menopause
    • anemia, which occurs when the body doesn’t produce enough red blood cells
    • infections
    • nausea, diarrhea, or vomiting
    • mucositis, which is a condition that causes inflammation and soreness in the mouth, throat, and stomach

    Talk to your doctor about any concerns you may have. They can help you weigh the risks and complications against the potential benefits of this procedure.

    Side-effects of a bone marrow transplant

    After your bone marrow transplant, you may have some side-effects, such as diarrhoea, which should be mostly temporary.

    Straight after your transplant, the levels of blood cells in your body will be very low. This may cause the following.

    • Having a low immunity to infections, due to a lack of white blood cells.
    • Anaemia – a condition in which you have too few red blood cells or not enough haemoglobin in your blood. Haemoglobin is a protein found in red blood cells that carries oxygen and carbon dioxide around your body in your bloodstream.
    • Bleeding because of a lack of platelets in your blood – these normally help your blood to clot.
    • Problems eating as a result of feeling sick, not feeling hungry or having a sore mouth after treatment.
    You may need to have a blood transfusion to increase your levels of platelets and red blood cells.

    More information
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    Thursday, 13 February 2014

    Stem Cell Therapy for treatment of Brain & Spine, Neurological Disorders

    A stem cell (blood or marrow) transplant is the infusion, or injection, of healthy stem cells into your body to replace damaged or diseased stem cells. A stem cell transplant may be necessary if your bone marrow stops working and doesn't produce enough healthy stem cells. A stem cell transplant also may be performed if high-dose chemotherapy or radiation therapy is given in the treatment of blood disorders such as leukemia, lymphoma or multiple myeloma. A stem cell transplant can help your body make enough healthy white blood cells, red blood cells or platelets, and reduce your risk of life-threatening infections, anemia and bleeding.

    Although the procedure to replenish your body's supply of healthy blood-forming cells is generally called a stem cell transplant, it's also known as a bone marrow transplant, peripheral blood stem cell transplant or an umbilical cord blood transplant, depending on the source of the stem cells. Stem cell transplants can use cells from your own body (autologous stem cell transplant), from a donor (allogeneic stem cell transplant) or from an identical twin (syngeneic transplant).

    IncurableNeurological Diseases that can be treated with Stem Cell Therapy


    1.      1. Spinal Cord Injuries
    2. Muscular Dystrophy
    3. Multiple Sclerosis
    4. Brain Stroke
    5. Cerebral Palsy
    6. Dementia
    7. Autism
    8. Motor Neuron Dise.ase
    9. Sequelae of Head Injury
    10. Sequelae of Neurological Infections
    11. Genetic Neurological Disorders

    Types of  Stem Cell Transplants

    There are two main types of transplants – autologous and allogeneic.
    An autologous transplant uses the patient's own stem cells, collected in advance and returned to them after they receive high doses of chemotherapy. In an allogeneic transplant the stem cells are donated from another person, a genetically matched stem cell donor. While all transplants are serious procedures, allogeneic transplants are more complicated and therefore carry more short and long-term risks than autologous transplants.

    The type of transplant you are given depends on a number of factors. These include the type of disease you have, your age, general health, the condition of your marrow and whether you would benefit by receiving donated stem cells, or whether your own stem cells can be used.

    A stem cell transplant is not necessarily the best option for everyone. The transplant process is demanding both physically and emotionally, and some people may not be fit enough to tolerate it. Also, many people don't need a transplant and can be successfully treated using a less intensive approach. For others a transplant is the only option which offers a prospect of cure, or long term survival.
    Our strategy is to promote the recovery of neural function with a close integration of Neuro-regenerative (stem cell),  Neuro-protective (medications) and Neuro rehabilitative (physical/occupational/speech) therapies.

    This therefore combines the best of Neurobiological repair technologies and Neural restorative techniques. We recognize that even small functional gains may have a significant effect on the quality of life of our patients. Our treatment is individualized to the specific requirements of each patient.

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    Sunday, 5 January 2014

    Types of Bone Marrow Transplants - How the Bone Marrow Functions


    Bone marrow is the soft, spongy center of your bone where blood is produced. Marrow is filled with blood-producing cells, called stem cells, which develop into mature white blood cells, red blood cells or platelets.
    White blood cells of various kinds make up part of your immune system for fighting infections.Red blood cells are responsible for carrying oxygen throughout your body.Platelets clot your blood to prevent bleeding. Stem cells are constantly being produced by your bone marrow, and will develop into the types of cells your body needs.



    Most people who need to undergo a bone marrow transplant have cancer, such as leukemia or lymphoma. There are different types of bone marrow transplants. The type and severity of your disease determine what type of bone marrow transplant you will need.



    Allogeneic Bone Marrow Transplants

    An allogeneic bone marrow transplant involves receiving donor bone marrow or peripheral stem cells. This bone marrow transplant donor is genetically matched and can be related or unrelated to you. An autologous transplant involves receiving your own bone marrow or peripheral stem cells. A syngeneic bone marrow transplant involves receiving your identical twin's bone marrow or peripheral stem cells.


    Allogeneic Transplants

    An allogeneic bone marrow transplant involves receiving very high-doses of chemotherapy and/or radiation therapy, followed by the infusion of your donor's bone marrow or peripheral stem cells. The high-dose cancer fighting treatments are given to eliminate the cancer in your body. The infusion of the new marrow or peripheral stem cells during an allogeneic bone marrow transplant replaces the bone marrow destroyed by the chemotherapy and/or radiation therapy.
    You may be a potential candidate for an allogeneic bone marrow transplant if you have leukemia, aplastic anemia, myelodysplasia, myelofibrosis, high-grade lymphoma or other types of cancers.

    A non-myeloablative (“mini”) allogeneic bone marrow transplant involves receiving low-doses of chemotherapy and radiation therapy followed by the infusion of your donor's bone marrow or peripheral stem cells. The objective of the bone marrow transplant is to suppress your own bone marrow by receiving just enough chemotherapy and radiation therapy to allow your donor cells to engraft and grow within you. The hope is these donor cells will mount an immunologic attack against your underlying cancer, generating a response called the "graft-versus-leukemia" effect or “graftversus- cancer” effect.
    You may be a potential candidate for a mini allogeneic transplant if you have a slow growing, indolent disorder, such as chronic leukemia, multiple myeloma, myelodysplasia, low-grade lymphoma, and in some cases, renal cell carcinoma. The mini allogeneic transplant is not appropriate, for example, if you have fast-growing acute leukemia.

    Autologous Bone Marrow Transplants

    An autologous bone marrow transplant involves receiving very high-dose chemotherapy followed by the infusion of your previously-collected peripheral stem cells or bone marrow.
    The high-dose chemotherapy treatments are given to eliminate the cancer in your body. The infusion of your new marrow through a bone marrow transplant or peripheral stem cells replaces the bone marrow destroyed by the chemotherapy and/or radiation therapy.You may be a potential candidate for an autologous bone marrow transplant if you have lymphoma, multiple myeloma, Hodgkin's disease, germ cell cancer, breast cancer or certain types of leukemia.



    Bone marrow transplant procedure in India comprises two major activities: the harvesting of the stem cells and the transplantation of the stem cells.
    The procedure for harvesting stem cells is the same for both autologous and allogenic bone marrow transplants in India. Under general anaesthesia, bone marrow is extracted from major bone structure is such as the hip and the spine. There are no surgical incisions, just skin punctures to insert the needles. The harvested stem cells may need to be processed to make them fit for transplantation.

     In the second phase, the actual transplantation procedure is performed. All hospitals that perform bone marrow transplant procedure in India have a special and segregated bone marrow transplant unit which is highly sterile. This is because bone marrow transplant patients are susceptible to infections on account of lower levels of immunity.
    Prior to the procedure, catheters are inserted to allow administration of drugs, nutrition etc. Patients would receive medications such as antibiotics and antivirus to prevent as well as to treat infections of any kind. Patients scheduled for allogenic transplant will also receive special medications to prevent rejection of the donor cells by the patients immune system.
    Healthy stem cells are introduced into the body through the bloodstream, and no surgery is normally necessary. The stem cells upon reaching the bone marrow, engraft there and after a couple of weeks commence production of normal blood cells.

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